Impact of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphisms on mRNA expression in peripheral blood mononuclear cells
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概要
- 論文の詳細を見る
The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (p<0.05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs.
著者
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Suzuki Yoshiharu
Department Of Biology Tokyo Metropolitan University
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Hyodo Ichinosuke
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp
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Abei Masato
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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Abei Masato
Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Suzuki Yoshiharu
Department of Applied Chemistry, Faculty of Engineering, Keio University
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Hyodo Ichinosuke
Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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