Morphological Transformation and Phosphatidylserine Exposure in Erythrocytes Treated with Ribavirin
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概要
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The effects of intracellular ribavirin on morphology and redistribution of phosphatidylserine (PS) in human erythrocytes were examined. Erythrocytes were incubated with 1 mM ribavirin in the presence/absence of dipyridamole, an inhibitor of es-type nucleoside transporter. Intracellular ribavirin was accumulated in erythrocytes with the concentration of 1361 μM, which corresponds to the blood level in patients receiving ribavirin. Dipyridamole reduced ribavirin accumulation by 40.7% (807 μM) via inhibiting es-type nucleoside transporter on erythrocytes. Morphological transformation into echinocytic form was observed in 86.4% of the erythrocytes treated with ribavirin. Dipyridamole pre-treatment decreased the morphological change to 20.0%. Ribavirin increased the PS-exposing cells compared with control (2.15% vs. 0.87%). PS-exposing cells were also decreased by inhibiting ribavirin accumulation with dipyridamole (0.62%). The results suggest that intracellular ribavirin induces morphological change and PS exposure in erythrocytes and accelerates erythrophagocytosis in the reticuloendothelial system.
- 公益社団法人 日本薬学会の論文
著者
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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KOHDA Yukinao
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kohda Yukinao
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Hosono Hiroyuki
Department of Pharmacy, Tsukuba University Hospital
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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Homma Masato
Department of Pharmacy, Tsukuba University Hospital
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Kohda Yukinao
Department of Pharmacy, Tsukuba University Hospital
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HOSONO Hiroyuki
Department Engineering Science, Junior College, Nihon University
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