Stereochemistry and Putative Origins of Flavanones Found in Post-administration Urine of the Traditional Chinese Remedies Shosaiko-to and Daisaiko-to
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概要
- 論文の詳細を見る
Optically active flavanones, dihydrowogonin and dihydrooroxylin A, were found in the urine of healthy volunteers who orally received the traditional Chinese remedies Shosaiko-to and Daisaiko-to on separate occasions. These remedies, which consisted of dried extracts of Scutellariae Radix and other herbs, contained the metabolic precursors of the flavanones, but not the flavanones themselves, in stoichiometrically sufficient amounts. Structures and stereochemistry of the flavanones were elucidated by UV, circular dichroism (CD), electron impact (EI)-MS and ^1H-NMR analyses, showing that the biotransformations from the corresponding flavones, wogonin and oroxylin A, were stereoselective with a preference for the S-enantiomers. The putative origins of the flavanones were confirmed in terms of pharmacokinetics. Renal excretion-time data of the flavanones and the flavones suggested that the stereoselective transformations might have occurred in the intestinal tract as a result of microfloral metabolism before absorption.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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OKA Kitaro
Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Sciences
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Hirai M
Kobe Pharmaceutical University
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HOMMA Masato
Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University o
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Oka Kitaro
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Oka Kitaro
Department Of Clinical Pharmacology Tokyo University Of Pharmacy And Life Science
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Oka Kitaro
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Ohkura N
National Cardiovascular Center Res. Inst. Osaka
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Ohkura Naoki
Department Of Mechanical Engineering Graduate School Of Engineering Nagaoka University Of Technology
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Ohkura Naoki
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Sience
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Li Chuan
Department Of Life Sciences Chung Shan Medical University
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Oka K
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Homma Masato
Department Of Clinical Pharmacology Institute Of Cliniical Medicine University Of Tsukuba
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Li Chuan
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Li Chuan
Institute Of Medicine Chung Shan Medical And Dental University
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Ohkura Naoki
Department Of Biochemistry Osaka University Of Pharmaceutical Sciences
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