Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice

スポンサーリンク

概要

• 論文の詳細を見る

• Mammalian sialidases (NEU1, NEU2, NEU3 and NEU4) that remove sialic acids from glycoconjugates have been implicated in diverse cellular functions. Human sialidases are involved in the development of various disease states such as cancer, diabetes and arteriosclerosis. Unregulated acidic sialidase NEU1 activity is associated with the pathogenesis of lysosomal storage disorder (LSD) sialidosis, abnormal immune responses and cancer progression. Obesity is closely related to several chronic diseases such as diabetes, cardiovascular diseases, hyperlipidemia or hypertension that are associated with metabolic syndrome. We examined fluctuations in mRNA levels and sialidase activities of NEU1 in two strains of obese and diabetic mice to assess the involvement of NEU1 in obesity. The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice. Fluctuations in NEU1 activity might be associated with the pathological status of these tissues in obesity.

著者

• Nasui Miwako

  Department of Developmental Program, Faculty of Pharmaceutical Sciences Teikyo University

• Ohkura Naoki

  Department Of Biochemistry Osaka University Of Pharmaceutical Sciences

• Atsumi Gen-ichi

  Department of Medical and Pharmaceutical Sciences, School of Pharma-Sciences, Teikyo University

• Natori Yujin

  Department of Life and Health Sciences, School of Pharma-Sciences, Teikyo University

• Kihara-Negishi Fumiko

  Department of Life and Health Sciences, School of Pharma-Sciences, Teikyo University

• Nasui Miwako

  Department of Life and Health Sciences, School of Pharma-Sciences, Teikyo University

• Nasu Miwako

  Department of Life and Health Sciences, School of Pharma-Sciences, Teikyo University

関連論文

• Isolation and Amino Acid Sequence of a Phospholipase A_2 Inhibitor from the Blood Plasma of the sea Krait, Laticauda semifasciata
• Isolation and Amino Acid Sequence of a Phospholipase A_2 Inhibitor from the Blood Plasma of Agikistrodon blomhoffii siniticus.
• FGF10 AND GATA4 ARE INVOLVED IN THE DEVELOPMENT OF THE GLANDULAR STOMACH OF FETAL MOUSE(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Stereochemistry and Putative Origins of Flavanones Found in Post-administration Urine of the Traditional Chinese Remedies Shosaiko-to and Daisaiko-to
• Time Series Analysis on the Emission of Light from Methane-Air Lean Premixed Flames : Diagnostics of the Flame Instability
• Acidic Sialidase Activity Is Aberrant in Obese and Diabetic Mice

スポンサーリンク