Antioxidative Activity of 3-O-Octanoyl-(+)-Catechin, a Newly Synthesized Catechin, in Vitro
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概要
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The antioxidative activities of 3-O-octanoyl-(+)-catechin were studied in vitro. Free radical scavenging activities were tested by spectrophotometrically measuring 2, 2'-azinobis(3-ethylbenzothiazoline-6-sulphonate) (ABTS) radical cations, as well as by measuring luminol chemiluminescence induced by peroxyl radicals generated from 2, 2'-azinobis(2-amidinopropane) dihydrochloride (AAPH). The radical scavenging activities of the 3-O-octanoyl-(+)-catechin for ABTS radical cations and peroxyl radicals were less effective than the original (+)-catechin, but stronger than 6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-carboxylic acid (Trolox). Furthermore, 3-O-octanoyl-(+)-catechin unlike (+)-catechin did not effectively antagonize the decrease in the intrinsic fluorescence intensity of allophycocyanin induced by AAPH, which was measured as an index of protein damage. Conversely, 3-O-octanoyl-(+)-catechin demonstrated more potent antioxidative activity for the linoleic acid peroxidation induced by AAPH than (+)-catechin and Trolox. These findings suggest that the introduction of an octanoyl group at the 3-OH position in a (+)-catechin effectively quench the secondary products of lipid peroxidation without much loss of free radical scavenging activity.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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UESATO Shinichi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai University
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Nakagawa Kazuo
Dep. Of Food And Nutrition Kyoto Women's Univ.
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Nakagawa Kazuo
Department Of Materials Science And Engineering Muroran Institute Of Technology
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Nakagawa Kazuo
Department Of Food And Nutrition Faculty Of Home Economics Kyoto Women's University
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Fujii Seiko
Department of Food and Nutrition, Kyoto Women's University
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Ohgi Akiko
Department of Food and Nutrition, Kyoto Women's University
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Ohgi Akiko
Department Of Food And Nutrition Kyoto Women's University
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Fujii Seiko
Department Of Food And Nutrition Kyoto Women's University
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