A MODULATING ROLE OF TAURINE ON RELEASE OF ACETYLCHOLINE AND NOREPINEPHRINE FROM NEURONAL TISSUES
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概要
- 論文の詳細を見る
Effects of taurine (2-aminoethanesulfonic acid) on the uptake and release of <SUP>14</SUP>C-acetylcholine (<SUP>14</SUP>C-ACh) and <SUP>3</SUP>H-norepinephrine (<SUP>3</SUP>H-NE) in the superior cervical ganglion and cerebral cortex of the rat were studied. Taurine suppressed high potassium evoked release of <SUP>14</SUP>C-ACh and <SUP>3</SUP>H-NE from the rat superior cervical ganglia and cerebral cortical slices, while the drug did not modify <I>per se</I> the uptake and unstimulated (spontaneous) release of <SUP>14</SUP>C-ACh and <SUP>3</SUP>H-NE in these tissues. Furthermore, taurine inhibited the release of <SUP>3</SUP>H-NE from the crude synaptosomal (P<SUB>2</SUB>) fraction of the rat brain without affecting the uptake. These results suggest that taurine may act as a modulator of neuronal activity, possibly by stabilizing excitable membrane and by suppressing the release of neurotransmitter at synapses.
- 社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Nakagawa Kazuo
Department Of Food And Nutrition Faculty Of Home Economics Kyoto Women's University
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Muramatsu Makoto
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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Kakita Kiyohito
Department Of Neurosurgery Kyoto First Red Cross Hospital
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KAKITA Kiyohito
Department of Pharmacology, Kyoto Prefectural University of Medicine
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