SOME FACTORS AFFECTING ENZYME RELEASE FROM CEREBRAL LYSOSOMES : INHIBITORY EFFECTS OF LEAD
スポンサーリンク
概要
- 論文の詳細を見る
The mode of the inhibitory effect of lead ion on the release of enzymes from cerebral lysosomes isolated from young Wistar rats was examined. The incubation of cerebral lysosomes in a low pH medium or with adenosine triphosphate (1 mM) at neutral pH resulted in the decrease of the release of acid phosphatase (EC 3.1.3.2) and β-N-acetylglucosaminidase (EC 3.2.1.30) activities. Multivalent cations such as Mn<SUP>2+</SUP>, Co<SUP>2+</SUP> and La<SUP>3+</SUP> inhibited the enzyme release, while Ca<SUP>2+</SUP> facilitated the release. On the other hand, lead ion suppressed the Ca<SUP>2+</SUP>-Induced enzyme release, but this suppressive effect of lead ion was eliminated by the treatment of lysosomes with phospholipase C and phospholipase A<SUB>2</SUB>. These results suggest that lead ion may alter the ionic permeability of cerebral lysosomal membrane by reacting with membraneous phospholipids, and thus may prevent the release of lysosomal enzymes in vitro.
- 社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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NAKAGAWA Kazuo
Hygiene Laboratory, Department of Food Science, Kyoto Womans University
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ASAMI Masukichiro
Hygiene Laboratory, Department of Food Science, Kyoto Womans University
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NAKAGAWA Kazuo
Hygiene Laboratory, Department of Food Science, Kyoto Woman's University
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ASAMI Masukichiro
Hygiene Laboratory, Department of Food Science, Kyoto Woman's University
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