Effect of 1,3-Di-n-Butyl-7-(2-oxopropyl)-Xanthine (denbufylline) on metabolism and function of cerebral cholinergic neurons.
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概要
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Effect of denbufylline, a low K<SUB>m</SUB> phosphodiesterase inhibitor, on cerebral cholinergic neurons was investigated using male Wistar rats. Single administrations of denbufylline (3, 10 and 30 mg/kg, p.o.) decreased cerebral cortical, hippocampal and striatal acetylcholine (ACh) contents in a dose-dependent manner. However, denbufylline (30 mg/kg, p.o.) had no effect on the activities of ACh synthesizing and degrading enzymes in these brain areas. In vitro addition of denbufylline (10<SUP>-8</SUP> - 10<SUP>-4</SUP>M) produced no significant change in [<SUP>3</SUP>H]choline uptake in striatal slices, while denbufylline (10<SUP>-4</SUP>M) increased high (20 mM) potassium-evoked endogenous ACh release from striatal slices. Denbufylline (30 mg/kg, p.o.) increased cyclic AMP (cAMP) contents in the cerebral cortex, hippocampus and striatum. In vitro addition of dibutyryl cAMP (5 × 10<SUP>-3</SUP>M) also accentuated the high (20 mM) potassiumevoked endogenous ACh release from striatal slices. These results suggest that denbufylline may induce the facilitation of ACh turnover by enhancing endogenous ACh release via the increase of cAMP content in the brain.
- 公益社団法人 日本薬理学会の論文
著者
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Katsura Masashi
Department Of Mathematics Faculty Of Science Kyoto Sangyo University
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Hashimoto Tsuneichi
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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KATSURA Masashi
Department of Pharmacology, Kyoto Prefectural University of Medicine
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