Irsogladine Maleate May Preserve Gastric Mucosal Hydrophobicity Against Ethanol in Phospholipids Independent Way in Rats
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概要
- 論文の詳細を見る
Irsogladine maleate (IM) has been used as a mucosal protective agent, whose action is partially explained as enhancement of mucosal blood flow, increase of cellular cyclic AMP and facilitation of gap-junctional intercellular communication. Effect of IM on rat gastric mucosal hydrophobicity, one of the mucosal barrier properties, was investigated, in comparison with that of 16, 16-dimethyl prostaglandin E2 (dmPGE2). IM alone had no effect on mucosal hydrophobicity and mucosal phospholipids content. dmPGE2 alone did not change mucosal hydrophobicity significantly, but remarkably increased mucosal surface-active phospholipids. Intragastric administration of absolute ethanol significantly decreased gastric mucosal hydrophobicity and mucosal phospholipids content. IM could prevent the decrease in mucosal hydrophobicity by ethanol, maintaining the surface mucus gel layer and mucosal surface phospholipids almost as non-damaged control levels, whereas dmPGE2 also prevented the decrease in mucosal hydrophobicity by ethanol, with the surface epithelium being partially exfoliated and mucosal surface-active phospholipids showing remarkable enhancement. These results suggest that IM may preserve gastric mucosal hydrophobicity against ethanol, not through enhancement of mucosal phospholipids content like prostaglandin, but possibly through its reported stabilization action to the epithelial cell lining, which may preserve the surface epithelium with the mucous gel layer containing surface-active phospholipids, a possible origin of mucosal hydrophobicity.
- 社団法人 日本薬理学会の論文
- 1998-08-01
著者
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KATSURA Masashi
Department of Pharmacology, Kawasaki Medical School
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Kodama T
Yamaguchi Prefectural Hospital
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KASHIMA Kei
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Kashima Kei
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kashima Kei
Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kashima Kei
Third Department Of Internal Medicine And Kyoto Prefectural University Of Medicine
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TATSUMI Yoshihide
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KODAMA Tadashi
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Katsura Masashi
Department Of Pharmacology Kawasaki Medical School
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Katsura Masashi
Department Of Mathematics Faculty Of Science Kyoto Sangyo University
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Tatsumi Yoshihide
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kodama Tadashi
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kashima K
The Third Department Of Medicine Kyoto Prefectural University Of Medicine
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Kagawa Keizo
The Department Of Internal Medicine Fukuchiyama City Hospital
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TANINO Masamichi
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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OKUMA Seitaro
Department of Pharmacology, Kawasaki Medical School
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Okuma Seitaro
Department Of Pharmacology Kawasaki Medical School
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Tanino Masamichi
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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