Biological Significance of AFP Expression in Liver Injury Induced by CCL_4

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概要

• 論文の詳細を見る

• To clarify whether α-fetoprotein(AFP)expression in acute liver injury is related to hepatic regeneration, we measured serum AFP and GOT in rats with CCI_4-induced liver injury, and investigated proliferating activity of AFP-positive cells using a combined technique of immunocytochemistry and autoradiography of ^3H-thymidine. Serum AFP reached a peak just after that of GOT. AFP-immunoreactivity was found in hepatocytes bordering necrotic area around central veins and ultrastructural findings showed apoptotic phenomenon in AFP-positive cells. The combined technique showed the presence of ^3H-thymidine grains in hepatocytes bordering the necrotic area, but the grains were not simultaneously seen in AFP-positive cells. Our findings suggest that AFP synthesis is related rather with cell death than with regeneration after severe hepatitis induced by CCI_4.

• 日本組織細胞化学会の論文

著者

• Okanoue T

  Division Of Gastroenterology Saiseikai Suita Hospital

• KASHIMA Kei

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okanoue Takeshi

  Yosanoumi Hospital

• Kashima K

  京都府立医科大学 3内

• Kashima Kei

  Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Kashima Kei

  Third Department Of Internal Medicine And Kyoto Prefectural University Of Medicine

• Mori Takahiro

  Department Of Molecular Gastroenterology Hepatology Kyoto Prefectural University School Of Medical S

• Tanaka S

  Shizuoka Univ. Shizuoka Jpn

• OKANOUE Takeshi

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Okanoue Takeshi

  Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Tanaka S

  Department Of Biology Faculty Of Science Shizulka University

• IWAI Masaki

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Morikawa Teruhisa

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Muramatsu Akira

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Tanaka Saiyu

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Mori Takahiro

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Harada Yoshinori

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Ishi Masaru

  Internal Medicine, Saitama Prefectural Cancer Center

• Kashima K

  The Third Department Of Medicine Kyoto Prefectural University Of Medicine

• Iwai Masaki

  Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Iwai Masaki

  Department Of Molecular Gastroenterology Hepatology Kyoto Prefectural University School Of Medical S

• Kagawa Keizo

  The Department Of Internal Medicine Fukuchiyama City Hospital

• Tanaka Saiyu

  Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Muramatsu Akira

  Division Of Liver Diseases Department Of Internal Medicine Akashi Municipal Hospital

• Muramatsu Akira

  Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine

• Morikawa Teruhisa

  Department Of Molecular Gastroenterology Hepatology Kyoto Prefectural University School Of Medical S

• Ishii M

  Department Of Molecular Gastroenterology Hepatology Kyoto Prefectural University School Of Medical S

• Oka Takahiro

  Department Of Organ Transplant And Endoclinological Surgery Kyoto Prefectural University Of Medicine

• Iwai Masaki

  Third Department Of Internal Medicine And Kyoto Prefectural University Of Medicine

• Harada Yoshinori

  Department Of Pathology Kyoto Prefectural University School Of Medical Science

• Okanoue Takeshi

  Third Department Of Internal Medicine Kyoto Prefectural Unicersity Of Medicine

• Kashima Kei

  Third Department Of Internal Medicine Kyoto Prefectural Unicersity Of Medicine

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