Effect of (1,3-di-n-butyl-7-(2-oxopropyl)-xanthine) (denbufylline), a low Km phosphodiesterase inhibitor, on striatal acetylcholine release in the rat: Analysis using cerebral microdialysis.
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概要
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Effect of oral and intraperitoneal administrations of [1, 3-di-n-butyl-7-(2-oxopropyl)-xanthine] (denbufylline) on acetylcholine (ACh) content and release in the rat striatum was investigated. Denbufylline (3, 10 and 30 mg/kg, p.o.) decreased striatal ACh contents in a dose-dependent manner. Denbufylline administration (30 mg/kg, i.p.) produced no significant change in the spontaneous release of ACh, while it increased a high potassium-evoked ACh release in the striatum. These results suggest that denbufylline may be a drug inducing the increased release of ACh in the brain.
- 公益社団法人 日本薬理学会の論文
著者
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Katsura Masashi
Department Of Mathematics Faculty Of Science Kyoto Sangyo University
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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