Effect of buflomedil (4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride) on neurotransmitters in the striatum and substantia nigra.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of buflomedil [4-(1-pyrrolidinyl)-1-(2, 4, 6-trimethoxyphenyl)-1-butanone hydrochloride] administration on central monoaminergic systems was investigated using male Wistar rats. Single administration of buflomedil (300 mg/kg, p.o.) induced a significant increase in the content of homovanillic acid without altering the content of dopamine (DA) and also caused a significant decrease in choline acetyltransferase (ChAT) activity in the corpus striatum. In addition, both L-glutamic acid decarboxylase activity (GAD) and γ-aminobutyric acid (GABA) content showed a significant decrease in the substantia nigra following a single administration of buflomedil. These results indicate that buflomedil enhances DA turnover in the nigro-striatal DA pathway, possibly by activating nigro-striatal DA neurons, or by suppressing striatal cholinergic interneurons and/or striatonigral GABAergic neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Hashimoto Tsuneichi
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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KODA Hirohumi
Department of Pharmacology, Kyoto Prefectural University of Medicine
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