EFFECT OF ORGANOPHOSPHORUS COMPOUNDS ON ACETYLCHOLINE SYNTHESIS IN BRAIN
スポンサーリンク
概要
- 論文の詳細を見る
Effects of parathion and di-isopropyl fluorophosphate (DFP) on acetylcholine (ACh) synthesis in the mouse brain were investigated. In addition to well known cholinesterase (ChE) inhibition, parathion showed inhibitory effects on the activity of synaptosomal choline acetyltransferase (ChAc), and on the uptake of [<SUP>14</SUP>C-methyl]-choline and ACh synthesis in subcellular fractions of the brain. DFP inhibited ChE activity, but had no significant effects on the choline uptake and ACh synthesis <I>per se</I>. Possible significance of these findings in the pharmacological actions of organophosphorus compounds is briefly discussed.
- 社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Muramatsu Makoto
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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KURIYAMA Kinya
Department of Pharmacology, Kyoto Prefectural University of Medicine
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