PRETREATMENT WITH TAURINE FACILITATES HEPATIC LIPID PEROXIDE FORMATION ASSOCIATED WITH CARBON TETRACHLORIDE INTOXICATION
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概要
- 論文の詳細を見る
Pretreatment with taurine (3% aqueous solution, p.o., for 3 days) facilitated lipid peroxide formation in the rat liver associated with carbon tetrachloride (CCl<SUB>4</SUB>: 2 ml/kg, b.w., i.p.) administration. The taurine pretreatment had no effect on the metabolism of <SUP>14</SUP>CCl<SUB>4</SUB> in hepatic microsomes and antioxidant content in the liver, but significantly enhanced the CCl<SUB>4</SUB>-induced increase in hepatic Ca<SUP>++</SUP> content. Ca<SUP>++</SUP> increased the Fe<SUP>++</SUP>-induced NADPH-dependent lipid peroxidation in hepatic microsomes, and this Ca<SUP>++</SUP> effect was also enhanced by CCl<SUB>4</SUB> treatment. These results suggest that the increment of hepatic lipid peroxidation following CCl<SUB>4</SUB> administration may be, at least in part, due to the increment of Fe<SUP>++</SUP>-induced NADPH-dependent lipid peroxidation by Ca<SUP>++</SUP>, and the taurine pretreatment may affect the increase by increasing Ca<SUP>++</SUP> content in the liver.
- 社団法人 日本薬理学会の論文
著者
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NAKASHIMA Toshiaki
Department of Internal Medicine, Saiseikai Kyoto Hospital
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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TAKINO Tatsuro
Departments of Internal Medicine, Kyoto Prefectural University of Medicine
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Nakashima Toshiaki
Department Of Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate Scho
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