Stress Induced Alterations in Striatal GABA<SUB>A</SUB> Receptor Complex
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概要
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The effect of cold-immobilized stress on the γ-aminobutylic acid (GABA)/ benzodiazepine (BZP) receptor complex in the rat striatum was examined. The stressful manipulation induced a significant decrease in the amount of [<SUP>3</SUP>H]muscimol binding sites in the striatal particulate fraction. On the other hand, [<SUP>3</SUP>H]flunitrazepam (FLN) binding and the enhancing effect of FLN or secobarbital on the [<SUP>3</SUP>H]muscimol binding to the striatal particulate fraction were not influenced by the stress treatment. These results suggest that cold-immobilized stress may selectively change GABA<SUB>A</SUB> receptor binding without altering BZP receptor binding as well as the functional coupling between GABA<SUB>A</SUB> and BZP receptors.
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Hashimoto Tsuneichi
Department Of Pharmacology Kyoto Prefectural University Of Medicine
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ZHANG Ming-Yu
Department of Pharmacology, Kyoto Prefectural University of Medicine
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