THERAPEUTIC EFFECT OF TAURINE ADMINISTRATION ON CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY
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概要
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To determine the therapeutic efficacy of taurine administration on liver injury, the effect of taurine on hepatic lipid peroxide level following carbon tetrachloride (CCl<SUB>4</SUB>) administration was investigated. To CCl<SUB>4</SUB> intoxicated rats (CCl<SUB>4</SUB>, 2 ml/kg, i.p.), 3 ml of a 10% aqueous solution of taurine was administered after CCl<SUB>4</SUB> administration (at 12, 16, and 20hr after), and rats were sacrificed at 24 hr after CCl<SUB>4</SUB> administration in order to estimate the level of lipid peroxides in the liver. The decrease of hepatic lipid peroxidation induced by CCl<SUB>4</SUB> was noticed in the taurine-treated rats. Taurine had no effect on mixed function oxidase activity in hepatic microsomes as well as no effect on hepatic antioxidant content in the CCl<SUB>4</SUB>-intoxicated rats. Hepatic taurine content decreased significantly 12 and 24 hr after CCl<SUB>4</SUB> administration, whereas oral administration of taurine to CCl<SUB>4</SUB>-intoxicated rats was able to protect these rats from hepatic taurine depletion. These results suggest that hepatic taurine may play a critical role on the protection of hepatocytes against hepatotoxins such as CCl<SUB>4</SUB> and the administration of taurine may be useful in the treatment of hepatotoxininduced liver injury.
- 社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Nakashima Toshiaki
Department Of Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate Scho
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TANIKO Tatsuro
Departments of Internal Medicine, Kyoto Prefectural University of Medicine
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