ETHANOL INDUCED ALTERATIONS OF AXOPLASMIC FLOW IN RETINAL GANGLION CELLS
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概要
- 論文の詳細を見る
Effects of acute ethanol administration on the axoplasmic flow in retinal ganglion cells of rats were studied by intraocular injection of <SUP>3</SUP>H-1-leucine. Ethanol induced a facilitation of the fast axoplasmic flow without affecting the slow axoplasmic flow. Pretreatment with colchicine almost completely eliminated the fast flow in both control and ethanol-treated rats, while cycloheximide did not significantly affect the facilitation of the fast flow induced by ethanol. The extent of ethanol-induced changes in the fast flow did not directly correlate with the level of ethanol or acetaldehyde in the blood. Neither adrenalectomy nor hypophysectomy modified significantly the facilitation of the fast axoplasmic flow due to ethanol administration. Present results indicate that ethanol-induced facilitation of the fast axoplasmic flow is not due to the direct effect of ethanol or acetaldehyde or to changes in pituitaryadrenal function.
- 公益社団法人 日本薬理学会の論文
著者
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Kuriyama Kinya
Department Of Health Promoting Acupuncture And Moxibution Meiji University Of Oriental Medicine
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Yamasaki Yoshihide
Department of Pharmacology, Kyoto Prefectural University of Medicine
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