(+)-Catechin with Cu2+ Induces Protein Modifications via Reactive Oxygen Species-independent Pathway
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概要
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Catechins show various biological activities, for which beneficial as well as adverse effects have been observed. Unfavorable properties of catechins are often attributed to reactive oxygen species (ROS) production. Our aim was to investigate whether catechins affect protein via ROS generation. We examined the effects on bovine serum albumin (BSA) of (+)-catechin with Cu2+ as well as ascorbate with Cu2+. The ascorbate/Cu2+ system is a metal-catalyzed oxidation (MCO) system and can produce ROS. Both systems altered spectroscopic properties of albumin, increased protein carbonyl content and resulted in several conformational changes. Catalase and hydroxyl radical scavengers markedly suppressed protein modifications by the ascorbate/Cu2+ systembut not those by the (+)-catechin/Cu2+ system. As far as we observed, no protein alteration induced by the (+)-catechin/Cu2+ system correlated with ROS formation.
- 公益社団法人 日本薬学会の論文
著者
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Nakagawa Kazuo
Department Of Food And Nutrition Faculty Of Home Economics Kyoto Women's University
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Kaku Maiko
Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women's University
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Kaku Maiko
Department of Food and Nutrition, Kyoto Women's University
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Kaku Maiko
Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women's University
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Nakagawa Kazuo
Department of Food and Nutrition, Kyoto Women's University
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