Comparative Examination of Anti-proliferative Activities of (-)-Epigallocatechin Gallate and (-)-Epigallocatechin against HCT116 Colorectal Carcinoma Cells(Pharmacognosy)
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概要
- 論文の詳細を見る
We compared anti-proliferative activities of(-)-epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) against HCT116 colorectal carcinoma cells. These catechins inhibited cell growth to nearly the same extent at low cell confluency in plates. However, their inhibitory effect grew weaker as cell confluence increased, and this tendency was more conspicuous for EGC than for EGCG. Both EGCG and EGC activated the phosphorylation of the major MAPKs, ERK, JNK, and p38, in the HCT116 cells as in many other established human cancer cells though to different extents. Cell cycle analyses, DNA fragmentation assays, and TUNEL assays as well as Western blot assays suggested that these catechins inhibited cell growth through mitogen-activated protein kinase (MAPK)-mediated apoptosis rather than cell cycle regulation.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
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Kushima Yukihiro
関西大学 化学生命工学部生命･生物工学
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Baba Kimiye
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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UESATO Shinichi
Department of Biotechnology, Faculty of Engineering, Kansai University
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KUMAGAI Ayako
Department of Biotechnology, Faculty of Engineering, Kansai University
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NAGAOKA Yasuo
Department of Biotechnology, Faculty of Engineering, Kansai University
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Sakaguchi Minoru
Osaka University Of Pharmaceutical Sciences
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INABA Hiroyuki
Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan
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KUSHIMA Yukihiro
Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan
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MATSUMOTO Yoshinori
Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kan
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Uesato S
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Sakaguchi Minoru
Osaka University
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Nagaoka Y
Kansai Univ. Osaka Jpn
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Kumagai Ayako
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Inaba Hiroyuki
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Uesato S
Dep. Of Life Sci. And Biotechnology Fac. Of Chemistry Materials And Engineering Kansai Univ.
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Matsumoto Yoshinori
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Matsumoto Yoshinori
Department Of Applied Physics And Physico-informatics Keio University
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai University:high Technology Research Center
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Inaba Hiroyuki
Department Of Earth Sciences Toyama University
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Nagaoka Yasuo
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Nagaoka Yasuo
Fac. Of Chemistry Materials And Bioengineering Kansai Univ.
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Kushima Yukihiro
Department of Life Science and Biotechnology, Faculty of Chemistry, Material and Bioengineering, Kansai University
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