Conversion of Deoxypodophyllotoxin to Podophyllotoxin-related Compounds by Microbes(Biological Chemistry)
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概要
- 論文の詳細を見る
Penicillium F-0543 (unidentified) converted deoxypodophyllotoxin (DPT), a major constituent (2.4%) of seeds of Hernandia ovigera L., to epipodophyllotoxin (EPT), which is the basic skeleton of the excellent anticancer agent, etoposide, in the high yield of 100%. Although the conversion rate varied, eight type cultures of Penicillium sp. tested also converted DPT to EPT. Three species of Aspergillus niger converted DPT to PT, but the yield were very low. Furthermore, it was found that many microbes examined converted DPT to a non-active substance, deoxypicropodophyllin (DPP), which is widely distributed in higher plants.
- 社団法人日本農芸化学会の論文
- 1989-03-23
著者
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Kondo K
Research Laboratories Yamasa Shoyu Co. Ltd.
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Baba Kimiye
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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OGURA Masaji
Department of Agricultural Chemistry, Faculty of Agriculture, Utsunomiya University
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TSUJIBO Hiroshi
Osaka University of Pharmaceutical Sciences
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INAMORI Yoshihiko
Osaka University of Pharmaceutical Sciences
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Ogura M
Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University
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Kondo Kazuhiko
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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MIDORIKAWA YUICHIRO
Research Laboratories, Yamasa Shoyu Co., Ltd.
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KOZAWA MITSUGI
Osaka College of Pharmacy
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Kozawa Mitsugi
Osaka University Of Pharmaceutical Sciences
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OGURA Masaru
Research Laboratories, Yamasa Shoyu Co., Ltd.
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Kozawa M
Osaka Univ. Pharmaceutical Sciences Matsubara Jpn
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Midorikawa Yuichiro
Research Laboratories Yamasa Shoyu Co. Ltd.
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Midorikawa Yuichiro
Research Laboratories Yamasa Corporation
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Inamori Yoshihiko
Osaka College Of Pharmacy
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