Intracellular Accumulation of Phenazine Antibiotics Produced by an Alkalophilic Actinomycete. I. Taxonomy, Isolation and Identification of the Phenazine Antibiotics(Microbiology & Fermentation Industry)
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概要
- 論文の詳細を見る
An alkalophilic actinomycete, strain OPC-15, which was isolated from a soil sample, produced phenazine antibiotics in the mycelium. From the results of taxonomic studies, this strain was designated as Nocardiopsis dassonvillei OPC-15. N. dassonvillei OPC-15 produced different phenazine antibiotics under different culture conditions (incubation period, incubation temperature and temperature shift). 1,6-Dihydroxyphenazine (III) was obtained from the mycelium on incubation for 6〜8 days at 27℃, while 1,6-dihydroxyphenazine 5,10-dioxide (I, iodinin) was isolated on incubation for 6 days at 27℃ followed by further incubation for 2 days at 4℃. 1,6-Dihydroxyphenazine 5-monooxide (II) was purified from the mycelium cultured under both these two sets of cultural conditions. These results suggest that the N-oxidation of III was catalyzed enzymatically with the temperature shift from 27℃ to 4℃.
- 社団法人日本農芸化学会の論文
- 1988-02-23
著者
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TSUJIBO Hiroshi
Osaka University of Pharmaceutical Sciences
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INAMORI Yoshihiko
Osaka University of Pharmaceutical Sciences
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SATO Takashi
Osaka University of Pharmaceutical Sciences
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INUI Masaru
Osaka University of Pharmaceutical Sciences
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YAMAMOTO Hisashi
Osaka University of Pharmaceutical Sciences
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Inamori Yoshihiko
Osaka College Of Pharmacy
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