Quercetin Enhances Tumorigenicity Induced by N-Ethyl-N'-Nitro-N-Nitrosoguanidine in the Duodenum of Mice

スポンサーリンク

概要

• 論文の詳細を見る

• Quercetin, a flavonoid, widely distributed in many fruits and vegetables, is well known to have an antitumor effect despite its mutagenicity. In this study, we examined the effect of dietary quercetin on duodenum-tumorigenicity of mice induced by a chemical carcinogen, N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). Eight-week-old male C57BL/6 mice were divided into 4 groups ; ENNG without quercetin (group A), ENNG with 0.2% quercetin (group B), ENNG with 2% quercetin (group C), and 2% quercetin without ENNG (group D). ENNG was given in drinking water for the first 4 weeks, and thereafter quercetin was given in a mixed diet. At week 20, the average number of duodenal tumors per mouse was significantly higher in group C (mean±SE, 7.26±1.75, p<0.05) than in group A (2.32±0.31). The size of the duodenal tumors increased significantly in group B (1.79±0.09 mm, p<0.001) compared with group A (1.43±0.09 mm). In contrast, no duodenal tumor was induced in group D. The present findings suggest that excessive intake of quercetin occasionally is a risk factor for carcinogenesis of some specific organs such as the upper intestine.

• 日本衛生学会の論文

著者

• SUGIHARA HIROYUKI

  Department of Pathology, Kyoto Prefectural University of Medicine

• Sakai Toshiyuki

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Sugihara Hiroyuki

  Dep. Of Pathology Shiga Univ. Of Medical Sciences

• Sugihara Hiroyuki

  Dept. Of Pathol. Fukui Medical School

• MATSUKAWA Yoshizumi

  Department of Preventive Medicine, Kyoto Prefectural University of Medicine

• NISHINO Hoyoku

  Biochemistry, Kyoto Prefectural University of Medicine

• YOSHIDA Mitsunori

  Department of Preventive Medicine, Kyoto Prefectural University of Medicine

• KATSURA Kanade

  2nd Department of Pathology, Kyoto Prefectural University of Medicine

• TAKAMATSU Tetsurou

  2nd Department of Pathology, Kyoto Prefectural University of Medicine

• OKUZUMI Junichi

  1st Department of Surgery, Kyoto Prefectural University of Medicine

• MATSUMOTO Katsuhiko

  Hyogo Institute for Oriental Medicine

• SATO Fumiko

  Department of Preventive Medicine, Kyoto Prefectural University of Medicine

• Katsura Kanade

  2nd Department Of Pathology Kyoto Prefectural University Of Medicine

• Sugihara Hiroyuki

  Department Of Pathology Fukui Medical School

• Yoshida Mitsunori

  Department Of Ergonomics Graduate School Of Design Kyushu University

• Yoshida Mitsunori

  Department Of Preventive Medicine Kyoto Prefectural University Of Medicine

• Takamatsu Tetsurou

  2nd Department Of Pathology Kyoto Prefectural University Of Medicine

• Matsukawa Yoshizumi

  Department Of Preventive Medicine Kyoto Prefectural University Of Medicine:hyogo Institute For Orien

• Matsukawa Yoshizumi

  Department Of Gastroenterology Hyogo Prefectural Amagasaki Hospital

• Okuzumi Junichi

  1st Department Of Surgery Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Biochemistry Kyoto Prefectural University Of Medicine

• Sato Fumiko

  Department Of Preventive Medicine Kyoto Prefectural University Of Medicine:hyogo Institute For Orien

• Sugihara H

  Department Of Pathology Shiga University Of Medical Science

関連論文

• APPLICATION OF MICROWAVE IRRADIATION IN SURGICAL PATHOLOGY; IMPROVEMENT OF MICROSCOPIC-IMAGE OF CRYOSTAT SECTIONS AND EXPLORATION IN RAPID METALLIC STAININGS (Microwave Fixation in Histochemistry)
• Association of Cumulative Cyclosporine Dose with Its Irreversible Nephrotoxicity in Japanese Patients with Pediatric-Onset Autoimmune Diseases(Biopharmacy)
• Prediction of systemic exposure to cyclosporine in Japanese pediatric patients
• Change in Pharmacokinetics of Model Compounds with Different Elimination Processes in Rats during Hypothermia
• Reversal Effects of Ca2+ Antagonists on Multidrug Resistance via Down-regulation of MDR1 mRNA
• Three-Dimensional, but not Two-Dimensional, Culture Results in Tumor Growth Enhancement after Exposure to Anticancer Drugs
• Knock-down of Sorcin Induces Up-regulation of MDR1 in HeLa Cells(Molecular and Cell Biology)
• Effect of Rabeprazole on MDR1-Mediated Transport of Rhodamine 123 in Caco-2 and Hvr100-6 Cells(Biopharmacy)
• Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer
• MDR1 T-129C Polymorphism can be Predictive of Differentiation, and Thereby Prognosis of Colorectal Adenocarcinomas in Japanese(Biopharmacy)
• MDR1, MRP1 and MRP2 Genotypes and In Vitro Chemosensitivity in Japanese Patients with Colorectal Adenocarcinomas
• Intradermal Concentration of Hydroquinone after Application of Hydroquinone Ointments Is Higher than Its Cytotoxic Concentration(Biopharmacy)
• MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
• MDR1 C3435T Polymorphism Is Predictive of Later Onset of Ulcerative Colitis in Japanese(Biopharmacy)
• Histone Deacetylase Inhibitors : Promising Agents for 'Gene-Regulating Chemoprevention' and 'Molecular-Targeting Prevention' of Cancer
• INK4 Family : A Promising Target for 'Gene-Regulating Chemoprevention' and 'Molecular-Targeting Prevention' of Cancer
• Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells
• Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells
• Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis
• IL-1β Genotype-Related Effect of Prednisolone on IL-1β Production in Human Peripheral Blood Mononuclear Cells under Acute Inflammation(Pharmacology)
• Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
• Effect of Therapeutic Moderate Hypothermia on Multi-drug Resistance Protein 1-Mediated Transepithelial Transport of Drugs
• 急性炎症下におけるヒト末梢血単核球MDR1の遺伝子型に依存した遺伝子発現量ならびに機能低下
• Comparison of Synthetic DNA Templates with Authentic cDNA Templates in Terms of Quantification by Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction(Analytical Biochemistry)
• Effects of Acid and Lactone Forms of Eight HMG-CoA Reductase Inhibitors on CYP-Mediated Metabolism and MDR1-Mediated Transport
• 電流検出方式DNAチップを用いた複数遺伝子型同時判定法のMDR1遺伝子への応用
• A Case of Acute Pancreatitis Associated With Cationic Trypsinogen N29T Mutation
• Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma
• New treatment method for developmental dysplasia of the hips after walking age : arthroscopic reduction with limboplasty based on the findings of preoperative imaging
• Active Oxygens and Cancer Cachexia
• Identification of JTP-70902, a p15^-inductive compound, as a novel MEK1/2 inhibitor
• Inhibitory Effects of Cancer Cell Proliferation by Novel Histone Deacetylase Inhibitors Involve p21/WAF1 Induction and G_2/M Arrest(Medicinal Chemistry)
• P-gp誘導 Caco-2 細胞 : P-gp高感度 Assay System の構築
• Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer : Initial experience at Kobe University
• Rapid detection of the fluoroquinolone resistance-associated ParC mutation in Neisseria gonorrhoeae using TaqMan probes
• Presence of a mutation in ponA1 of Neisseria gonorrhoeae in numerous clinical samples resistant to various β-lactams and other, structurally unrelated, antimicrobials
• Granulocyte-colony stimulating factor producing urothelial carcinoma of renal pelvis
• Ovarian carcinoma recurring as carcinosarcoma
• Chemoprevention of colorectal cancer in Japan : a brief introduction to current clinical trials
• Cell proliferation and cytodifferentiation of rat thyroid tumors
• Lectin Histochemistry of rat thyroid tumors
• Simultaneous Cytofluorometry of SH and SS groups in nuclear protein and DNA of mice human hepatocytes(IV)
• Cell Cycle-dependent Modulation of Promoter Activities of RB and WAF1/Cip1 Genes
• Proapoptotic Effect of a Dietary Supplement : Water Soluble Chitosan Activates Caspase-8 and Modulating Death Receptor Expression
• Down-Regulation of FXYD3 Is Induced by Transforming Growth Factor-β Signaling via ZEB1/δEF1 in Human Mammary Epithelial Cells
• Combined Staining with DAPI and Rhodamine-labeled Lectin for DNA cytofluorometry (II)
• Combined Staining with DAPI and Rhodamine-labeled Lectin for DNA-cytofluorometry
• Local labeling ^3H-thymidine autoradiography and DNA cytofluorometry for the study of stomach cancers of dogs
• PII-30 Lineage-specific modes of intestinal expression in undifferentiated-type gastric carcinomas
• Enzymohistochemical studies on ALPase Isozymes in human and dog gastric carcinoma cells
• Growth Inhibition of A549 Human Lung Adenocarcinoma Cells by L-Canavanine Is Associated with p21/WAF1 Induction
• ラット胃・十二指腸液逆流モデルを用いて検討した呼吸器疾患と微量誤嚥との関連性の組織学的検討
• A case of ischemic colitis during pregnancy
• High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model
• Quercetin Enhances Tumorigenicity Induced by N-Ethyl-N'-Nitro-N-Nitrosoguanidine in the Duodenum of Mice
• Bromodeoxyuridine Induces p53-dependent and -independent Cell Cycle Arrests in Human Gastric Carcinoma Cell Lines(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
• Role of p53 in Growth Suppression by Bromodeoxyuridine in Human Gastric Cancer Cell Lines
• Evaluation of Human P-Glycoprotein (MDR1/ABCB1) ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements : Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs(Biopharmacy)
• Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines
• Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells
• PA3-3 Foot Trajectory Pattern and Perception of Foot Position while Stepping over an Obstacle in the Elderly(Proceedings of The 8th International Congress of Physiological Anthropology)
• Relapse of duodenal ulcers after successful eradication of Helicobacter pylori in gastric ulcer patients
• "Combination-oriented molecular-targeting prevention" of cancer : a model involving the combination of TRAIL and a DR5 inducer
• Color Image Analysis of Mucin Distribution in Intramucosal Signet-ring Cell Carcinoma
• Lectin Histochemical Study of Squamous Carcinoma in the Head and Neck Region
• バルプロ酸誘発高アンモニア血症に対するCPS1 4217C>A遺伝子多型の影響
• A Conversational Picture Processing System by Computer
• Dynamic range of Red / Green ratio in comparative genomic hybridization
• IB-26 Dynamic alteration in domain constitution of E-cadherin during intramucosal cell differentiation and extramucosal invasion in signet ring cell carcinoma of the stomach(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
• FXYD3 Protein Involved in Tumor Cell Proliferation Is Overproduced in Human Breast Cancer Tissues
• ラット胃・十二指腸液逆流モデルを用いて検討した呼吸器疾患と微量誤嚥との関連性の組織学的検討
• A real time phonetically based spoken word recognition system and recognizer for unspecified speakers
• Post-operative infection and prophylactic antibiotic administration after radical cystectomy with orthotopic neobladder urinary diversion
• Prediction of systemic exposure to cyclosporine in Japanese pediatric patients

もっと見る 閉じる

スポンサーリンク