DRUG-CARRIER PROPERTY OF ALBUMIN MICROSPHERES IN CHEMOTHERAPY. III. EFFECT OF MICROSPHERE-ENTRAPPED 5-FLUOROURACIL ON EHRLICH ASCITES CARCINOMA IN MICE

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概要

• 論文の詳細を見る

• To examine the possibility of utilizing albumin microspheres as drug-carriers, an in vitro release of 5-fluorouracil (5-FU) from albumin microspheres was examined and the effect of intraperitoneally injected drug-carrying microspheres on Ehrlich ascites carcinoma in mice was studied. In vitro release characteristics determined by dialysis experiments showed that 5-FU release continued over one week. We also noted that drug release in the peritoneum of ascites-bearing mice continued over one week and that their life-span increased. Furthermore, the microspheres were phagocytized in vivo by the ascites cells. Our results suggest that albumin microspheres containing 5-FU may represent an effective system of drug delivery with prolonged action.

• 公益社団法人日本薬学会の論文

著者

• Sugibayashi Kenji

  Faculty of Pharmaceutical Sciences, Josai University

• Morimoto Yasunori

  Faculty of Pharmaceutical Sciences, Josai University

• Morimoto Yasunori

  Faculty Of Pharmaceutical Sciences Josai University

• NADAI Tanekazu

  Faculty of Pharmaceutical Sciences, Setsunan University

• AKIMOTO Masayuki

  Faculty of Pharmaceutical Sciences, Josai International University

• KATO YOSHIO

  Faculty of Pharmaceutical Sciences, Josai University

• Sugibayashi Kenji

  Faculty Of Pharmaceutial Sciences Josai University

• Nadai Tanekazu

  Faculty Of Pharmaceutical Sciences Josai University

• Kato Yoshio

  Faculty Of Pharmaceutical Sciences Josai University

• Akimoto Masayuki

  Faculty Of Pharmaceutical Science Josai International University

• Akimoto Masayuki

  Faculty Of Pharmaceutical Sciences Josai University

• Kato Yoshio

  Faculty Of Engineering Shinshu University

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