Effects of Sodium or Glucose Exclusion from the Incubation Medium on Drug Transfer across Rat Jejunal Membrane in Vitro : An Electrophysiological Study(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of buffer components, glucose and sodium, on the passive transfer of sulfanilic acid (SA) and sulfaguanidine (SG) across isolated rat jejunal membranes were investigated, together with their effects on the transmural potential difference.(PD) and the membrane resistance (R_m). Glucose or sodium exclusion from bathing solutions significantly increased the mucosal-to-serosal transfer of both drugs. Glucose exclusion caused an irreversible reduction in PD, and the active transfer of L-phenylalanine (L-Phe) was also inhibited. However, effects of sodium exclusion on PD and the transfer of SA were reversible. The addition of phloridzin (Phl) to the mucosal solution induced the effect similar to that of glucose exclusion. In contrast, R_m was not significantly altered by the exclusion of glucose or the addition of Phl. It is clear that environmental conditions which reduce the active transport activity of the membrane enhance the membrane permeability to drugs.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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Sezaki H
Setsunan Univ. Osaka Jpn
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Sezaki Hitoshi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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KIMURA TOSHIKIRO
Faculty of Pharmaceutical Sciences, Kyoto University
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Yamashita S
Setsunan Univ. Osaka Jpn
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NADAI Tanekazu
Faculty of Pharmaceutical Sciences, Setsunan University
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YAMASHITA Shinji
Faculty of Pharmaceutical Sciences, Setsunan University
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MASADA Mikio
Faculty of Pharmaceutical Sciences, Setsunan University
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SAITOH HIDETAKA
Faculty of Pharmaceutical Sciences, Josai University
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ABE KENJI
Faculty of Pharmaceutical Sciences, Josai University
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NAKANISHI KUNIO
Faculty of Pharmaceutical Sciences, Setsunan University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
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Masada Mikio
Faculty Of Pharmaceutical Sciences Setsunan University:department Of Hospital Pharmacy Chest Disease
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Nadai Tanekazu
Faculty Of Pharmaceutical Sciences Setsunan University:department Of Hospital Pharmacy Chest Disease
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Nadai Tanekazu
Faculty Of Pharmaceutical Sciences Josai University
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Yamashita Shinji
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Kunio
Faculty Of Pharmaceutical Sciences Setsunan University:department Of Hospital Pharmacy Chest Disease
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Nakanishi Kunio
Faculty Of Pharmaceutical Sciences Setsunan University
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Yamashita S
Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Nadai T
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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Kimura T
Faculty Of Pharmaceutical Sciences Okayama University
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Abe Kenji
Faculty Of Pharmaceutical Sciences Josai University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Setsunan University:faculty Of Pharmaceutical Sciences Okayama Un
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Saitoh Hidetaka
Faculty Of Pharmaceutical Sciences Josai University
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Kimura Toshikiro
Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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Nakanishi Kunio
Faculty of Pharmaceutical Science, Setsunan University
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