STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY : PHYSICOCHEMICAL FACTORS AFFECTING ABSORPTION FROM HAMSTER CHEEK POUCH
スポンサーリンク
概要
- 論文の詳細を見る
A new experimental method using a hamster cheek pouch in vivo for studying absorption processes across the keratinized oral mucous membrane was developed and some characteristics of the oral-mucosal absorption were clarified. A possitive correlation between the absorption rate and the lipophilicity was observed in 18 aromatic compounds examined. The absorption of ionizable compounds was poor in the ionized form. These results suggest that the absorption from the keratinized hamster cheek pouch is due to a passive diffusion mechanism and obeys pH-partition hypothesis. The systemic transfer of salicylic acid after intra-cheek-pouch administration could be approximated by the first-order absorption model including a lag time process and the plasma levels found were consistent with this model.
- 公益社団法人日本薬学会の論文
著者
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KUROSAKI Yuhji
Faculty of Pharmaceutical Sciences, Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
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Okada Yumiko
Faculty Of Pharmaceutical Sciences Okayama University
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Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Okayama University
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Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Kyoto University
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Nakayama T
Faculty Of Pharmaceutical Sciences Okayama University
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Nakayama Taiji
Faculty Of Pharmaceutical Sciences Okayama University
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Aya Noriko(yamashita
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura T
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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