EFFECT OF TAURINE ON THE GASTRIC ABSORPTION OF DRUGS : COMPARATIVE STUDIES WITH SODIUM LAURYL SULFATE
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify the mechanism taurine-induced enhancement of drug absorption, some comparison was made between the actions of taurine and sodium lauryl sulfate (SLS), an anionic surfactant, by using the loop of rat stomach in situ. SLS enhanced the gastric absorption of aspirin and salicylamide, and the SLS-induced enhancement seems to be Na^+-dependent. SLS failed to enhance the absorption of both drugs when NaCl was completely replaced by mannitol or in the presence of ouabain even in the NaCl medium. In addition, even at the lower concentration of 0.05 mM, SLS enhanced the absorption of the two drugs, the extent of which is nearly corresponding to those of taurine. The actions of SLS and taurine on drug absorption are considered to have some similar points. The mechanism of the action was discussed in relation to the cyclic AMP system.
- 公益社団法人日本薬学会の論文
著者
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Sezaki H
Faculty Of Pharmaceutical Sciences Setsunan University
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SEZAKI Hitoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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Sezaki H
Setsunan Univ. Osaka Jpn
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Setsunan University
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KIMURA TOSHIKIRO
Faculty of Pharmaceutical Sciences, Kyoto University
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Kim Kyung
Faculty Of Electrical And Electronic Engineering Cheju National University
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Kim Kyung
Faculty Of Pharmaceutical Sciences Kyoto University
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KUROKAWA MISAO
Faculty of Pharmaceutical Sciences, Kyoto University
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Kurokawa Misao
Faculty Of Pharmaceutical Sciences Kyoto University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
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Sasaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Saitoh H
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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Kimura T
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Setsunan University:faculty Of Pharmaceutical Sciences Okayama Un
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