Effect of Pretreatment with Antibiotics on the Hydrolysis of Salicyluric Acid in Rabbit Intestinal Microorganisms
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概要
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The effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms was investigated. Latamoxef sodium (LMOX, 25 mg/kg/d, intravenously) and cephalexin (CEX, 16.7 mg/kg/d, orally) were administered for 1 or 3 d. The blood concentration of salicyluric acid and salicylic acid following oral, intracecal and rectal administration of salicyluric acid was determined. By the pretreatment with LMOX for 1 or 3 d, the blood concentration of salicylic acid following oral administration of salicyluric acid was slightly decreased. In rabbits pretreated with CEX for 3 d, the blood concentration of salicylic acid was detected at low concentration. By the pretreatment with LMOX and CEX, however, the decrease in the blood concentration of salicylic acid following rectal administration of salicyluric acid was not observed. Although the examination of population of intestinal microorganisms induced by the pretreatment with antibiotics was not performed, the metabolic activity of intestinal microorganisms may be changed.
- 公益社団法人日本薬学会の論文
著者
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
Faculty Of Pharmaceutical Sciences Nagasaki University
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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Asai Kumiko
Graduate School Of Biomedical Sciences Nagasaki University
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Ariyoshi Kimiyo
長崎大学 医歯薬学総合研究科
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SASAKI Hitoshi
Faculty of Pharmaceutical Sciences, Nagasaki University
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SHIBASAKI Juichiro
Faculty of Pharmaceutical Sciences, Nagasaki University
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Shibasaki J
School Of Pharmaceutical Sciences Nagasaki University
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HARAGUCHI Yoko
Faculty of Pharmaceutical Sciences, Nagasaki University
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ASAI Kumiko
Faculty of Pharmaceutical Sciences, Nagasaki University
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Sasaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Haraguchi Yoko
Faculty Of Pharmaceutical Sciences Nagasaki University
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Ariyoshi Kimiyo
Graduate School Of Biomedical Sciences Nagasaki University
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Sasaki Hitoshi
Faculty Of Engineering Takushoku University
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