EFFECT OF STRAICHT CHAIN FATTY ACIDS ON SEIZURES INDUCED BY PICROTOXIN AND PENTYLENETETRAZOLE IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
The effects of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole were studied in mice. After i.p. injection capric, lauric, myristic, palmitic and stearic acid delayed the onset of picrotoxin-induced clonic convulsion in a dose-dependent manner. The survival time was also prolonged by the pretreatment with lauric, myristic, palmitic and stearic acid. However, the onset of the clonic convulsion induced by pentylenetetrazole was delayed only by lauric acid. The prolongation of the survival time was also observed only in the animals pretreated with capric and lauric acid. These results suggest that the straight chain fatty acids examined in the present study possess anticonvulsant activity in mice.
- 公益社団法人日本薬学会の論文
著者
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
Faculty Of Pharmaceutical Sciences Nagasaki University
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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SASAKI Hitoshi
Faculty of Pharmaceutical Sciences, Nagasaki University
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SHIBASAKI Juichiro
Faculty of Pharmaceutical Sciences, Nagasaki University
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Shibasaki J
School Of Pharmaceutical Sciences Nagasaki University
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Miwa T
School Of Pharmaceutical Sciences Nagasaki University
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Sasaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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MIWA Takaichi
Faculty of Pharmaceutical Sciences, Nagasaki University
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KANETO Hiroshi
Faculty of Pharmaceutical Sciences, Nagasaki University
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Kaneto Hiroshi
Faculty Of Pharmaceutical Sciences Nagasaki University
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Sasaki Hitoshi
Faculty Of Engineering Takushoku University
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