高カロリー輸液無菌調製における異物混入の原因に関する調査解析

概要

論文の詳細を見る
Contamination of total parenteral nutrition (TPN) fluids is a problem occurring when preparing admixtures of them. In the present study, we carried out an investigation into the cause of contamination with a view to its prevention. For the TPN admixtures prepared in our pharmacy, we investigated the number prepared, their contents, the number that had contaminants and the nature of the contaminating substances. Contaminants were found in about 10% of the TPN admixtures and micro-infrared spectrophotometer analysis indicated that most of the contaminants were pieces of the rubber produced by coring. Further, an investigation of a correlation between TPN prescription contents and the incidence of contamination showed that the highest incidence of contamination occurred in preparations made by a particular pharmaceutical company. In order to prevent rubber particles from being produced, we need to be very careful when sticking the needle into the rubber stopper during the mixing of TPN admixtures. However as it is difficult to prevent contamination completely, we suggest checking TPN admixtures for contamination after mixing them and using in-line filters when they are administered to patients.
日本医療薬学会の論文
2005-03-10