ANTIGEN-INDUCED DECREASE OF SALICYLIC ACID ABSORPTION FROM THE SMALL INTESTINE IN ACTIVELY IMMUNIZED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Rats were intraperitoneally immunized with bovine γ-globulin (BGG) emulsified in incomplete Freund's adjuvant. Intestinal absorption of salicylic acid from the rat small intestine was examined by means of in situ recirculation technique. The disappearance of salicylic acid from the luminal solution was significantly decreased in rats challenged intravenously with BGG compared to saline as control. A significant decrease in absorption of salicylic acid was noted in rats immunized twice and three times, but not in rats immunized only once. The effect was maintained for at least 5 weeks after the third immunization, whereas it disappeared within 10 weeks. In normal rats, the decreased absorption of salicylic acid by the intravenous challenge with BGG was hardly observed at all. These findings suggest that the intestinal absorption of salicylic acid may be affected by systemic anaphylaxis in actively immunized rats.
- 公益社団法人日本薬学会の論文
著者
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YAMAMOTO Akira
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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NAKAMURA Junzo
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura J
Tokyo Coll. Pharmacy Tokyo Jpn
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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KIMURA Toshikiro
Department of Pharmaceutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
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TAKADA SHIGEYUKI
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
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Kimura Toshikiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Yamamoto Akira
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Kimura T
岡山大学 薬
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushuma
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Yamamoto A
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushima
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KIMURA TOSHIKIRO
Faculty of Pharmaceutical Sciences, Okayama University
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