Electrophysiological Studies on the Mechanism for Enhanced Intestinal Transport of Water-Soluble Compounds by Antibiotic Peptide Bacitracin
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概要
- 論文の詳細を見る
Bacitracin is an antibacterial cyclic dodecapeptide produced by Bacillus licheniformin. Besides antibacterial activity, it is reported to have a protease inhibitory activity and an absorption enhancing action. Here we determined the effects of bacitracin on transport of water-soluble dye fluoresceinisothiocyanate (FITC)-dextran across the rat intestinal mucosal membrane using an electrophysiological technique. Bacitracin enhanced the intestinal mucosal-to-serosal transport of FITC-dextran in concentration-dependent and pH-dependent manners. In particular, the addition of bacitracin to the mucosal side led to a remarkable enhancement of FITC-dextran transport across the colonic membrane. Furthermore, its exhibition of transport enhancement required the existence of metal divalent cations, Ca^<2+> and Mg^<2+>, in the mucosal compartment. Electrophysiological study using voltageclamp technique revealed that a relatively lower concentration of bacitracin (5 mM) enhanced the transport of 6-carboxyfluorescein via a paracellular pathway in the colonic membrane and higher concentration of bacitracin (20 mM) affects both transcellular and paracellular routes, resulting in significant enhancement of 6-carboxyfluorescein across the colonic membrane. These findings might provide the useful information for enhancing the intestinal transport of poorly a sbsorbable drugs by bacitracin which has multiple functions.
- 公益社団法人日本薬学会の論文
- 1999-08-15
著者
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YAMAMOTO Akira
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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DOI Masayuki
Department of Internal Medicine, Division of Cardiology, Sumitomo Besshi Hospital
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FUJITA Takuya
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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Fujita T
Division Of Oral Cytology And Cell Biology Department Of Developmental And Reconstructive Medicine N
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FUJITA Takuya
Ritsumeikan University College of Information Science and Engeneering
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Quan Ying-shu
Department Of Biopharmaceutics Kyoto Pharmaceutical University:cosmed Pharmaceutical Co. Ltd.
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Yamamoto Akira
Dep. Of Biopharmaceutics Kyoto Pharmaceutical Univ.
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Fujita T
Ritsumeikan University College Of Information Science And Engeneering
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Fujita Takuya
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Doi Masayuki
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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KURIBAYASHI Daisuke
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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NAKAMOTO Yuko
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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Fujita T
Showa College Of Pharmaceutical Sciences
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Nakamoto Yuko
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Fukushima Tohru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Setsunan University
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村西 昌三
京都薬大
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushuma
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Kuribayashi Daisuke
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Department Of Anatomy School Of Medicine University Of Tokushima
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