AN ASSESSMENT OF GASTRIC ULCERS IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The permeability of gastric wall barrier to phenolsulfonphthalein (phenol red), a poorly absorbed drug, was examined as an index of an assessment of gastric mucosal damages in vivo. The urinary recovery after oral administration of phenol red and the ulcer index of the stomach were significantly increased in rats subjected to restraint and water immersion stress. Gastric absorption of phenol red, examined by means of in situ loop technique, was increased significantly in stressed rats. However, the urinary recovery of the dye after intravenous administration did not change in ulcerated rats compared with the control. These findings suggest that the increase in the urinary recovery of phenol red is due to the increased gastric absorption. The healing period of 12 d was enough to restore to control levels both the ulcer index and the urinary recovery of the dye. Both indices remained nearly at control level by the pretreatment with atropine sulfate. Good correlation between extent of gastric damage and urinary excretion of phenol red was obtained within single groups of animals. This method may be utilized as a simple and noninvasive screening test for an assessment of gastric mucosal damages in vivo.
- 公益社団法人日本薬学会の論文
著者
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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SEZAKI Hitoshi
Faculty of Pharmaceutical Sciences, Kyoto University
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Nakamura J
Tokyo Coll. Pharmacy Tokyo Jpn
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki H
Setsunan Univ. Osaka Jpn
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Sezaki Hitoshi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
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Sezaki Hitoshi
Departments Of Pharmacy Faculty Of Pharmaceutical Sciences Setsunan University
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Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Setsunan University
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HAMAURA TAKESHI
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
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Hamaura T
Kyoto Univ.
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KIMURA TOSHIKIRO
Faculty of Pharmaceutical Sciences, Kyoto University
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YAMAMOTO AKIRA
Faculty of Pharmaceutical Sciences, Kyoto University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
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Kimura T
岡山大学 薬
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Yamamoto A
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yamamoto Akira
Faculty Of Engineering Kyoto University.
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KIMURA TOSHIKIRO
Faculty of Pharmaceutical Sciences, Okayama University
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