TRANSPORT CHARACTERISTICS OF p-ACETAMIDOBENZOIC ACID IN BRUSH BORDER MEMBRANE OF RAT SMALL INTESTINE
スポンサーリンク
概要
- 論文の詳細を見る
Brush border membrane vesicles of rat small intestinal mucosa were prepared by the modified calcium precipitation method in order to investigate the intestinal secretion mechanism of p-acetamidobenzoic acid (Ac-PABA). The release rate of [^<14>C]-Ac-PABA from preloaded vesicles was much faster than that of p-aminobenzoic acid (PABA) and was enhanced by the addition of unlabelled Ac-PABA in the outer medium. In contrast, the membrane transfer rate of Ac-PABA across the egg lecithin liposomes was slower than that of PABA. The contribution of a carrier-mediated transport mechanism in the brush border membrane to the intestinal secretion of Ac-PABA was suggested.
- 公益社団法人日本薬学会の論文
著者
-
SEZAKI Hitoshi
Faculty of Pharmaceutical Sciences, Kyoto University
-
Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
-
Yasuhara Masato
(present Address) Department Of Pharmacy Kyoto University Hospital
-
KIMURA TOSHIKIRO
(Present address) Faculty of Pharmaceutical Sciences, Okayama University
-
Kimura Toshikiro
(present Address) Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- Biliary Excretion of Mitomycin C Dextran Conjugates in Relation of Physicochemical Characteristics of Carrier Dextran
- EFFECT OF MEDIUM-CHAIN GLYCERIDES (MGK^[○!R]) ON THE INTESTINAL ABSORPTION AND THE HEPATOBILIARY TRANSPORT OF BROMTHYMOL BLUE
- STUDY ON THE ACTION OF PERCUTANEOUS PENETRATION ENHANCERS : EFFECT ON VARIOUS DRUGS WITH DIFFERENT PHYSICOCHEMICAL PROPERTIES
- Analysis of Drug Penetration through Skin Considering Donor Concentration Decrease
- EFFECTS OF MITOMYCIN C, 5-FLUOROURACIL AND CYCLOPHOSPHAMIDE ON DRUG ABSORPTION, ENZYME ACTIVITIES AND MUCOSAL LIPID COMPOSITION OF INTESTINE
- TRANSPORT CHARACTERISTICS OF p-ACETAMIDOBENZOIC ACID IN BRUSH BORDER MEMBRANE OF RAT SMALL INTESTINE
- EFFECT OF SURFACTANTS ON THE ABSORPTION OF p-AMINOBENZOIC ACID FROM THE RAT INTESTINE
- COMPARATIVE STUDIES ON THE ABSORPTION MECHANISM OF p-AMINOBENZOIC ACID AND p-ACETAMIDOBENZOIC ACID FROM THE RAT INTESTINE
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT SMALL INTESTINE IN SITU
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT INTESTINE IN VITRO
- EVALUATION OF DRUG DISPOSITION IN BRAIN BY MOMENT ANALYSIS (II)
- INVESTIGATIONS OF INFLUX AND ACCUMULATION PROCESSES OF β-LACTAM ANTIBIOTICS AND THEIR ROLE IN THE TRANSMURAL TRANSFER ACROSS RAT JEJUNUM
- FURTHER INVESTIGATIONS ON THE TRANSPORT MECHANISM OF CEPHALEXIN AND AMPICILLIN ACROSS RAT JEJUNUM
- ELECTROPHYSIOLOGICAL APPROACH TO THE ACTION OF TAURINE ON RAT GASTRIC MUCOSA
- New Methods to Evaluate Intestinal Drug Absorption Mediated by Oligopeptide Transporter from In vitro Study using Caco-2 Cells
- Quantitative Evaluation of the Gastrointestinal Absorption of Protein into the Blood and Lymph Circulation
- ANALYSIS OF ACTION MECHANISM OF PERCUTANEOUS PENETRATION ENHANCER BASED ON PHYSIOLOGICAL SKIN DIFFUSION MODEL
- IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
- EFFECT OF SYNTHETIC SURFACTANTS ON DRUG ABSORPTION IN THE PRESENCE OF A PHYSIOLOGIC SURFACTANT, SODIUM TAUROCHOLATE, IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS. II
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS.I
- AN ASSESSMENT OF GASTRIC ULCERS IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : EFFECT OF ANAPHYLAXIS ON THE ABSORPTION OF SALICYLIC ACID FROM THE RAT SMALL INTESTINE
- QUANTITATIVE ANALYSIS OF DRUG DISPOSITION : APPLICATION OF STATISTICAL MOMENT THEORY TO LOCAL PERFUSION SYSTEM
- CONTROL OF IN VIVO FATE OF PROTEIN DRUGS USING CHEMICAL MODIFICATION WITH SUGARS
- Design and Evaluation of Monoclonal Antibody-Antitumor Agent Conjugate
- EFFECT OF TEMPERATURE ON INTESTINAL TRANSFER AND TISSUE UPTAKE OF SULFANILAMIDE AND AMINOPROPYRON IN VITRO
- CELLULAR INTERACTION AND ANTITUMOR ACTIVITY OF MITOMYCIN C PRODRUGS
- URINARY EXCRETION CHARACTERISTICS OF A POLYMERIC PRODRUG OF MITOMYCIN C, MITOMYCIN C-DEXTRAN CONJUGATE
- ENHANCED LYMPHATIC DELIVERY OF MIYOMYCIN C BY POLYMERIC MODIFICATION
- EFFECT OF TAURINE ON THE GASTRIC ABSORPTION OF DRUGS : COMPARATIVE STUDIES WITH SODIUM LAURYL SULFATE
- EFFECT OF TAURINE ON THE GASTROINTESTINAL ABSORPTION OF DRUGS-IONIC REQUIREMENT FOR THE ACTION
- SODIUM ION-DEPENDENCY OF TAURINE-INDUCED ENHANCEMENT OF DRUG ABSORPTION FROM RAT STOMACH IN SITU
- MECHANISM OF THE ABSORPTION OF WATER-SOLUBLE DRUGS FROM THE GASTROINTESTINAL TRACT : ABSORPTION OF β-LACTAM ANTIBIOTICS FROM RAT SMALL INTESTINE
- CARRIER-MEDIATED TRANSPORT SYSTEMS FOR AMINOPENICIL-LINS IN RAT SMALL INTESTINE
- CHARACTERIZATION OF AMINOCEPHALOSPORIN TRANSPORT ACROSS RAT SMALL INTESTINE
- EFFECT OF TAURINE ON DRUG ABSORPTION FROM THE RAT GASTROINTESTINAL TRACT
- EFFECT OF COMPLEXATION WITH DEXTRAN SULFATE ON THE LYMPHATIC DELIVERY OF BLEOMYCIN FOLLOWING INTRASTITIAL ADMINISTRATION
- PHARMACEUTICAL STUDIES ON LIPOSOMES : IMPROVEMENT OF ENTRAPPING EFFICIENCY FOR WATER SOLUBLE DRUGS BY FREEZING METHOD
- Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine
- ANTITUMOR ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN C ENTRAPPED IN LIPOSOME OR O/W EMULSION
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS
- DIFFERENCES IN EFFECTS ON DRUG ABSORPTION BETWEEN DIHYDROXY AND TRIHYDROXY BILE SALTS
- ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION
- DEVELOPMENT OF BIFUNCTIONAL DELIVERY SYSTEM FOR SELECTIVE TRANSFER OF DRUG INTO LYMPHATICS VIA ENTERAL ROUTE AND TRANSFER MECHANISM
- ABSORPTION OF 5-FLUOROURACIL FROM VARIOUS REGIONS OF GASTROINTESTINAL TRACT IN RAT. EFFECT OF MIXED MICELLES
- ENHANCED INTESTINAL PERMEABILITY TO MACROMOLECULES. I. EFFECT OF MONOOLEIN-BILE SALTS MIXED MICELLES ON THE SMALL INTESTINAL ABSORPTION OF HEPARIN
- Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine