Anti-proliferative Effect of Toremifene and Tamoxifen on Estrogen Receptor-lacking Anaplastic Thyroid Carcinoma Cell Lines
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概要
- 論文の詳細を見る
The antitumor effects of toremifene were studied in vitro using 10 anaplastic thyroid carcinoma cell lines and were compared with those of tamoxifen. The antitumor effect of toremifene was dose-dependent and the IC_<50> values for these cell lines ranged 20.1-58.5 μM. Although the cell lines expressed multidrug resistance gene mRNA, multidrug resistance-associated protein gene mRNA and insulin-like growth factor-1 (IGF-1) receptor mRNA to various degrees, nine of them lacked estrogen receptor expression as evaluated by immunocytochemistry. These data indicate that toremifene, as well as tamoxifen, is cytolytic at relatively high doses for multidrug-resistant anaplastic thyroid carcinoma cell lines.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
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KIMURA Masayuki
Department of Pharmacy Services, Saitama Medical Center
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Sugawara Isamu
Department of Molecular Pathology The Research Institute of Tuberculosis
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WATANABE Masatoshi
Department of Pathology, Mie University School of Medicine
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Sugawara I
Japan Anti‐tuberculosis Assoc. Tokyo Jpn
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Sugawara Isamu
Department Of Molecular Pathology Reserch Institute Of Tuberculslosis
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KISHINO Tohru
Department of Pharmacy, Saitama Medical Center, Saitama Medical School
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Kishino T
Department Of Pharmacy Saitama Medical Center Saitama Medical School:department Of Molecular Patholo
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Kimura Masayuki
Department Of Electrical Engineering Kyoto University
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Watanabe Masatoshi
Department Of Electrical And Electronics Engineering Faculty Of Engineering Tottori University
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Watanabe Masatoshi
Department Of Molecular Pathology The Research Institute Of Tuberculosis
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KISHINO Tohru
Department of Pharmacy Services, Saitama Medical Center, Saitama Medical University
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