(3-Amino-2-hydroxy)propoxy-3,4-dihydrocarbostyril誘導体の麻酔犬におけるβ-受容体遮断作用

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概要

• 論文の詳細を見る

• Anti-isoproterenol activity of 51 derivatives of 5-, 6-, 7-, and 8-(3-amino-2-hydroxy)-propoxy-3,4-dihydrocarbostyril was measured in an anesthetized dog. The derivatives which had 3-tert-butylamino-2-hydroxypropoxy in 5 or 8 position showed a potent activity. Among them, 5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochlo-ride (6) proved to be the most effective. 6 may be the most hopeful compound as an adrenergic β-receptor-blocking agent.

• 社団法人日本薬学会の論文
• 1974-05-25

著者

• 森 英雄

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 富永 道明

  大塚製薬株式会社徳島研究所

• 森 英雄

  大塚製薬株式会社徳島工場第一研究所

• 村上 七美

  大塚製薬株式会社徳島工場第一研究所

• 吉崎 国郎

  大塚製薬株式会社, 徳島工場第一研究室

• 藪内 洋一

  大塚製薬株式会社, 徳島工場第一研究室

• 新谷 成之

  大塚製薬株式会社, 徳島工場第一研究室

• 吉崎 国郎

  大塚製薬株式会社 徳島工場第一研究室

• 藪内 洋一

  大塚製薬徳島研究所

• 新谷 成之

  大塚製薬株式会社 徳島工場第一研究室

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

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