Anti-plasmin Inhibitor. VI. : Structure of Phlorofucofuroeckol A, a Novel Phlorotannin with Both Dibenzo-1,4-dioxin and Dibenzofuran Elements, from Ecklonia kurome OKAMURA

概要

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Phlorofucofuroeckol A (1), a novel phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, has been isolated from the brown alga Ecklonia kurome OKAMURA as a potent anti-plasmin inhibitor. Its structure has been elucidated to be 1,11-di(3,5-dihydroxyphenoxy)-benzofuro[3,2-a]dibenzo[b, e][1,4]dioxin-2,4,8,10,14-pentaol on the basis of the spectral data, in particular, by means of negative nuclear Overhauser effect (NOE) and long-range carbon-proton couplings (^2J<CH> and ^3J<CH>). Phlorofucofuroeckol A inhibited the action of α_2-macroglobulin (IC<50>=1.0μg/ml) and α_2-plasmin inhibitor (IC<50>=0.3μg/ml), the main plasmin inhibitors in plasma.
社団法人日本薬学会の論文
1990-01-25