97(P37) フクギの化学成分と生理活性(ポスター発表の部)
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概要
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In the course of our search for new neurotrophic factor-like substance and superoxide anion scavenger in natural product, we have studied chemical constituents in the wood of Garcinia subelliptica belonging to Guttiferae. Phytochemical data indicate that Garcinia species are rich in xanthones with various biological activities, and also the methanol extract of G. subelliptica exhibits antioxidant activity. Extensive studies on chemical components in the EtOAc soluble portion of title plant resulted in the isolation of fourteen new xanthones 1〜14, two new benzophenones 15 and 16, and six new phloroglucin derivatives 23〜28 named subellinone and garsubellins A〜E with a tetrahydrofuran ring in addition to the known xanthones. Their structures have been elucidated mainly on the basis of srectroscopic data and confirmed by converting them into the corresponding known compounds. In this paper, the structure of garsubellin A (24) are solely discussed in detail. All the compounds isolated at present study were tested for their antioxidant properties using three in vitro assay systems, viz., antilipidperoxidation activity in rat brain homogenates, free radical scavenging activity of α,α-diphenyl-β-picrylhydrazyl radical and superoxide anion scavenging activity in the xanthine-xanthine oxidase system. The results are summarized in Table 2. In particular, 1,4,5-trihydroxyxanthone (10) and symphoxanthone (21) could scavenge approximately 80% of superoxide anion at 5μgml_<-1>. Assay results imply that antioxidative xanthones should have a catechol part or a 1,4-hydroquinone moiety as a common structural unit. Further, garciniaxanthone B (2) was found to enhance not only neurite outgrowth but also choline acetyltransferase activity (ChAT) at 10μM in primary culture of rat cerebral hemisphere 10 days after seeding, whereas garsubellin A (24) could increase ChAT activity by 54% at 10μM in comparison with a control culture containing 0.5% EtOH in culture of P 10 rat septal neurons.
- 天然有機化合物討論会の論文
- 1997-07-20
著者
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高橋 絵美
徳島文理大薬
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福山 愛保
徳島文理大・薬
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児玉 三明
徳島文理大・薬
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福山 愛保
徳島文理大薬
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高橋 宏暢
徳島文理大学薬
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三並 博行
徳島文理薬
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三並 博行
徳島文理大薬
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木下 美穂
徳島文理大薬
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桑山 温子
徳島文理大薬
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吉澤 豊吉
日本メクトロン
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児玉 三明
徳島文理大薬
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Kodama M
Otsuka Pharmaceutical Co. Ltd.
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高橋 宏暢
徳島文理大学生薬研究所
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高橋 宏暢
徳島文理大学 生薬研究所
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