34 Sulfomycin Iの構造(口頭発表の部)

概要

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Structure 1 was proposed for sulfomycin I, an antibacterial peptide antibiotic produced by Streptomyces viridochromogenes subsp. sulfomycini ATCC 29776. In addition to the sub-units a-d assigned earlier, the incorporation of the sub-units e-i in 1 was established based on the structures of mild acid hydrolysis products (2a, 2b, 3a, and 4a, 4b) of the intact antibiotic. These sub-units were connected by using the results of long-range ^<13>C-^1H couplings and NOE (Fig. 1) summarized in Charts 4 and 5 to give the novel macrocyclic structure 1. ^1H and ^<13>C NMR data fully analyzed by various 2D techniques supported the structure. It was also suggested that structurally related peptide antibiotic, berninamycin, should contain the sub-unit h instead of berninamycinic acid moiety assigned previously.
天然有機化合物討論会の論文
1987-07-25