Anti-plasmin Inhibitor. V. : Structures of Novel Dimeric Eckols Isolated from the Brown Alga Ecklonia kurome OKAMURA

概要

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6,6'-Bieckol (1), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (4), and 8,8'-bieckol (2), bispolyphenols with a dibenzo-1,4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (α_2-macroglobulin and α_2-plasmin inhibitor) and some proteases have been examined.
社団法人日本薬学会の論文
1989-09-25