Brine Shrimp Lethality Test Active Constituents and New Highly Oxygenated Seco-prezizaane-Type Sesquiterpenes from Illicium merrillianum
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概要
- 論文の詳細を見る
In the study of bioactive substances in Illicium plants, the methanol extract of I.merrillianum showed brine shrimp lethalicy test(BST)activity at 200μg/ml. Bioassay-guided fractionation of the BST active fractions resulted in the isolation of 4-O-methyleudesm-11-en-4α-ol, eudesmol-11-en-4α-ol and(-)-hinokinin as potent BST active compounds. On the other hand, four new highly oxygenated seco-prezizaane-type sesquiterpenes, merrilliortholactone(1), 2α-hydroxycycloparvifloralone(2), 2α-hydroxycycloparviflorolide(3), and 2α-hydroxyanisatin(4)were isolated from the BST-inactive polar fractions. The structures of new compounds were elucidated by extensive analyses of spectral data. Furthermore, the absolute configuration of 3 was established by the modified Mosher's method. Compounds 1-4 showed neither BST activity at 100μg/ml nor neurite outgrowth-promoting activity.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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福山 愛保
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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福山 愛保
徳島文理大薬
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Huang Jian-mei
Faculty Of Pharmaceutical Sciences Beijing University Of Chinese Medicine
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FUKUYAMA Yoshiyasu
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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YANG Chun-Shu
Faculty of Pharmaceutical Sciences, Beijing University of Chinese Medicine
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HUANG Jian-Mei
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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NAKADE Kousuke
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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KONDO Mamiko
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Yang Chun-shu
Faculty Of Pharmaceutical Sciences Beijing University Of Chinese Medicine
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Fukuyama Yoshiyasu
Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kondo M
Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Nakade Kousuke
Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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