Neuroprotective Effects of 2,5-Diaryl-3,4-dimethyltetrahydrofuran Neolignans(Pharmacognosy)

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概要

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• We previously reported the neurotrophic effects of talaumidin (1) from Aristolochia arcuata M_<ASTERS>. In the present study, we compared the neurotrophic and neuroprotective effects of six other 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignans isolated from the same plant, veraguensin (2), galgravin (3), aristolignin (4), nectandrin A (5), isonectandrin B (6), and nectandrin B (7), with compound 1 in primary cultured rat neurons. Compounds 3-7 promoted neuronal survival and neurite outgrowth, among which compounds 6 and 7 showed neurotrophic activity comparable with that of 1. Furthermore, compounds 1-7 protected hippocampal neurons against amyloid β peptide (Aβ_<25-35>)-induced cytotoxicity, while compounds 1 and 4-7 protected against neuronal death from l-methyl-4-phenylpyridinium ion (MPP^+)-induced toxicity in cultured rat hippocampal neurons.

• 公益社団法人日本薬学会の論文
• 2005-02-01

著者

• FUKUYAMA Yoshiyasu

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• MITSUMOTO Yasuhide

  Second Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd.

• Fukuyama Yoshiyasu

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Fukuyama Yoshiyasu

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Zhai Haifeng

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Zhai Haifeng

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Inoue Takako

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• MORIYAMA Miyako

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ESUMI Tomoyuki

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• MITSUMOTO Yasuhide

  Neurodegenerative Disease Research Group, Second Institute of New Drug Research, Otsuka Pharmaceutic

• Esumi T

  Tokushima Bunri Univ. Tokushima Jpn

• Esumi Tomoyuki

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Mitsumoto Yasuhide

  Second Institute Of New Drug Discovery Otsuka Pharmaceutical Co. Ltd.

• Moriyama Miyako

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

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