Studies on Antibacterial Agents. II. : Synthesis and Antibacterial Activities of Substituted 1,2-Dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic Acids

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概要

• 論文の詳細を見る

• A series of substituted 1,2-dihydro-6-oxo-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids for the treatment of systemic infections was synthesized via 7-bromo-3-ethylthio-4,5-difluoro-2-methylindole (3), which was prepared by Gassman's indole synthesis in excellent yield. The synthesized pyrroloquinolines were tested for their antibacterial activities. 8-Fluoro-1,2-dihydro-2-methyl-9-(4-methyl-1-piperazinyl)-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid showed a potent antibacterial activity against gram-positive and gram-negative bacteria.

• 社団法人日本薬学会の論文
• 1990-09-25

著者

• 上田 敬

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 石川 廣

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 宇野 哲之

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 宮本 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 富永 道明

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  大塚製薬株式会社微生物研究所

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 宮本 寿

  大塚製薬株式会社微生物研究所

• 宇野 哲之

  Third Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 石川 廣

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

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