Studies on Antibacterial Agents. III. : Synthesis and Antibacterial Activities of Substituted 1,4-Dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids

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概要

• 論文の詳細を見る

• A series of substituted 4-oxoquinoline-3-carboxylic acids having a methyl group at the 8-position was prepared and tested for their antibacterial activity. 7-(trans-3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1,4-dihydro-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid (21) exhibited highly potent antibacterial activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.

• 社団法人日本薬学会の論文
• 1990-09-25

著者

• 上田 敬

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 宮本 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 富永 道明

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 中川 量之

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 玉岡 寿

  大塚製薬株式会社微生物研究所

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 宮本 寿

  大塚製薬株式会社微生物研究所

• 大塚 達也

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 安芸 晋治

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

• 安芸 晋治

  Otsuka Pharmaceutical Co. Ltd.

• 大塚 達也

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

• 上田 敬

  2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd.,

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