5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3,4-dihydrocarbostyril Hydrochlorideの合成とそのβ-遮断作用について

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概要

• 論文の詳細を見る

• 5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride, the main metabolite of the new adrenergic β-blocking agent, 5-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril hydrochloride (Carteolol hydrochloride), was synthesized and its antagonism against the positive chronotropic and hypotensive actions of isoproterenol was examined in anesthetized dogs. This compound was found to be a little more active than Carteolol hydrochloride.

• 社団法人日本薬学会の論文
• 1976-05-25

著者

• 宇野 敏行

  大塚製薬株式会社徳島工場第三研究所

• 中川 量之

  2nd Tokushima Institute Of New Drugs Research Otsuka Pharmaceutical Co. Ltd.

• 中川 量之

  大塚製薬株式会社有機化学研究所

• 中川 量之

  大塚製薬株式会社徳島研究所

• 富永 道明

  大塚製薬株式会社徳島研究所

• 利根 斉

  Laboratories of Medicinal Chemistry

• 石原 高文

  大塚製薬株式会社徳島工場第三研究所

• 内多 稔

  大塚製薬株式会社徳島工場第一研究所

• 岡 公章

  大塚製薬株式会社徳島工場第一研究所

• 利根 斉

  大塚製薬株式会社徳島工場第一研究所

• 内多 稔

  大塚製薬(株)徳島研究所

• 富永 道明

  大塚製薬(株)徳島新薬第二研究所

• 内多 稔

  大塚製薬株式会社徳島工場

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