Antioxidative Effect of Sesamol and Related Compounds on Lipid Peroxidation

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概要

• 論文の詳細を見る

• The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe^<2+>, on the lipid peroxidation of rat liver microsomes induced by CCl_4 or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe^<2+> were demonstrated. Consequently, sesamol and related compounds, such as 3-methoxy-4-hydroxyquinone, isosafrol, isoeugenol, eugenol, 3,4-methylenedioxyaniline, catechol. hydroxyhydroquinone, 3,4-dimethoxyaniline and caffeic acid, echibited powerful inhibitory effects on the lipid peroxidation system investigated. In particular, isoeugenol was the most powerful inhibitor among all the sesamol-related compounds tested on the lipid peroxidation system. In addition, 1,2-methylenedioxybenzene, ferulic acid, and 3,4-methylenedioxynitrobenzene were also effective on the lipid peroxidation system of liposomes induced by Fe^<2+>. The correlation between the structures of sesamol-related compounds and their inhibitory effect is discussed.

• 公益社団法人日本薬学会の論文
• 1996-04-15

著者

• TOYOSHIMA Satoshi

  Department of Pathology, Kitakyushu Municipal Medical Center

• Shinoda M

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Shinoda Masato

  Department Of Geography Tokyo Metropolitan University

• Nakajin Shizuo

  Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

• Toyoshima S

  Pharmaceuticals And Medical Devices Agency

• Toyoshima Satoshi

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• UCHIDA Mihoko

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University

• Uchida Mihoko

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Nakajin Shizuo

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Shinoda Masato

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

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