An NADPH-Dependent Reductase in Neonatal Pig Testes That Metabolizes Androgens and Xenobiotics
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概要
- 論文の詳細を見る
We have isolated an NADPH-dependent reductase from neonatal pig testes that metabolizes andorogens and a variety of xenobiotics. This enzyme is distinct from 3α/β, 20β-hydroxysteroid dehydrogenase or its homologue, carbonyl reductase, as judged by its immunological and molecular properties and its much narrower specificity for steroids. This reductase and 3α/β, 20β-hydroxysteroid dehydrogenase may be part of a mechanism for regulating androgen levels the neonatal pig testes. Interestingly, we could not find multiple isoforms of 3α/β, 20β-hydroxysteroid dehydrogenase/carbonyl reductase in pig testes unlike human and rat testes and other organs in which multiple isoforms are expressed.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
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TOYOSHIMA Satoshi
Department of Pathology, Kitakyushu Municipal Medical Center
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Nakajin Shizuo
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Toyoshima Satoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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MINAMIKAWA Noriko
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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BAKER Michael
Department of Medicine, 0623B, University of California, San Diego
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Baker Michael
Department Of Medicine 0623b University Of California San Diego
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Nakajin Shizuo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Minamikawa Noriko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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