Effects of Various Chemicals Including Endocrine Discuptors and Analogs on the Secretion of Th1 and Th2 Cytokines from Anti CD3-Stimulated Mouse Spleen Cells
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概要
- 論文の詳細を見る
The in vitro effects of various chemicals, such as styrene dimers, styrene trimers, alkylphenols, phthalate esters, phytoestrogens, and organotin compounds, on the production of interferon-gamma (IFN-γ), a type 1 helper T-cells (Th 1) specific cytokine, and interleukin-4 (IL-4), a type 2 helper T-cells (Th2) specific cytokine, which are secreted from anti CD3-stimulated mouse spleen cells, were examined. These chemicals suspected of having an endocrine disrupter function and to which humans may become exposed via ingestlon through food, food containers, and food packaging. It was found the organotin compounds bis(tributyltin) oxide, tributyltin chloride, and dibutyltin dichloride at concentrations which did not elicit any cytotoxicity inhibited secretion of the Th1 and Th2 specific cytokines IFN-γand IL-4 at concentrations (0.01-0.03, 0.07-0.1, and 0.096-0.132μM for IC_<50>, respectively) that were much lower than those of the other chemicals. However, these butyltin compounds exhibited similar degrees of inhibitory effects on IFN-γand IL-4 secretion and did not selectively inhibit the secretion of one or the other cytokine. However, diphenyltin dichloride and phenyltin trichloride enhanced the secretion of IL-4 at the comparatively low concentrations of 0.3 μM and 1.0 μM, respectively, although these compounds significantly inhibited IFN-γsecretion at the same concentrations. In addition, 4-t-pentylphenol enhanced IL-4 secretion although it inhibited IFN-γsecretion at the comparatively high concentration of 30 μM. It was also found that some styrene trimers, phthalate esters and fiavonoids as well as the alkyl phenols octylphenois and nonylphenol among others, inhibited the secretion of both cytokines at comparatively high concentrations (< 30 μM).
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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Ohno Shuji
Hoshi Univ. School Of Pharmacy And Pharmaceutical Sci. Tokyo Jpn
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Ohno Shuji
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Nakajima Yonako
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Nakajin Shizuo
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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TOYOSHIMA Satoshi
Pharmaceuticals and Medical Devices Evaluation Center National Institute of Health Sciences
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NAKAJIN Shizuo
Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Toyoshima Satoshi
Pharmaceuticals And Medical Devices Evaluation Center National Institute Of Health Science
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Toyoshima Satoshi
Pharmaceutical And Medical Devices Evaluation Center National Institute Of Health Science
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Nakajin S
Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Nakajin Shizuo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Yano Kazuma
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Yano Kazuma
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Nakajima Yonako
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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