Organotin Compounds Suppress Testosterone Production in Leydig Cells from Neonatal Pig Testes
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概要
- 論文の詳細を見る
The in vitro effects of exposure to tributyltin chloride (TBT), dibutyltin dichloride (DBT), and triphenyltin chloride (TPT) on testosterone production in isolated Leydig cells from neonatal pig testes were examined. These organotin compounds strongly suppressed human chorionic gonadotropin (10 IU/ml) or 8-bromo-cAMP (0.1 mM) induced testosterone production when the cells were exposed to nontoxic concentrations. The suppression of testosterone production was dose-dependent over the concentration range of 0.03-0.3 μM for TBT and DBT, and 0.01-0.3 μM for TPT. These effective concentrations for the suppression of testosterone production were lower than that of the cytotoxic concentrations of the organotin compounds in Leydig cells and were equivalent to the accumulated concentration levels that were previously reported in marine organisms.
- 社団法人日本薬学会の論文
- 2003-12-01
著者
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Ohno Shuji
Hoshi Univ. School Of Pharmacy And Pharmaceutical Sci. Tokyo Jpn
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SATO Go
Department of Veterinary Science, National Institute of Infectious Diseases
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Ohno Shuji
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Sato G
Hokkaido Univ. Sapporo Jpn
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Sato Go
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Nakajima Yonako
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Nakajin Shizuo
Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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NAKAJIN Shizuo
Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Nakajin S
Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Nakajin Shizuo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Nakajima Yonako
Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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