Determination and Molecular Analysis of the Complete Genome Sequence of Two Wild-Type Rabies Viruses Isolated from a Haematophagous Bat and a Frugivorous Bat in Brazil

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概要

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• The complete genome sequences of two Brazilian wild-type rabies viruses (RABV), a BR-DR1 isolate from a haematophagous bat (Desmodus rotundus) and a BR-AL1 isolate from a frugivorous bat (Artibeus lituratus), were determined. The genomes of the BR-DR1 and BR-AL1 had 11,923 and 11,922 nt, respectively, and both encoded the five standard genes of rhabdoviruses. The complete nucleotide sequence identity between the BR-DR1 and BR-AL1 isolates was 97%. The BR-DR1 and BR-AL1 isolates had some conserved functional sites revealed by the fixed isolates, whereas both isolates had unique amino acid substitutions in the antigenic region IV of the nucleocapsid gene. Therefore, it is speculated that both isolates were nearly identical in virologic character. According to our phylogenetic analysis based on the complete genomes, both isolates belonged to genotype 1, and to the previously defined "vampire bat-related RABV lineage" which consisted of mainly D. rotundus- and A. lituratus-isolates; however, a branch pattern with high bootstrap values suggested that BR-DR1 was more closely related to the 9001FRA isolate, which was collected from a dog bitten by a bat in French Guyana, than to BR-AL1. This result suggests that the vampire bat-related RABV lineage includes Brazilian vampire bat and Brazilian frugivorous bat RABV and is further divided into Brazilian vampire bat and Brazilian frugivorous bat RABV sub-lineages. The phylogenetic analysis based on the complete genomes was valuable in discriminating among very closely related isolates.

著者

• ITO Fumio

  Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo

• SAKAI Takeo

  Nihon University Veterinary Research Center

• MOCHIZUKI Nobuyuki

  Nihon University Veterinary Research Center

• KOBAYASHI Yuki

  Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics

• SATO Go

  Department of Veterinary Science, National Institute of Infectious Diseases

• HIRANO Shinji

  Nihon University Veterinary Research Center

• ITOU Takuya

  Nihon University Veterinary Research Center

• Itou Takuya

  Nihon Univ. Veterinary Res. Center Kanagawa

• Ito Fumio

  Faculty Of Veterinary Medicine And Zootechny University Of Sdo Paulo

• SATO Go

  Nihon University Veterinary Research Center

• Sato Go

  Department Of Biochemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences

• Sakai Takeo

  Nihon Univ. Res. Center Kanagawa

• Kobayashi Y

  Nihon University Veterinary Research Center

• Kobayashi Yuki

  Graduate School Of Agriculture Hokkaido University

• Ito Fumio

  Faculty Of Veterinary Medicine And Zootechny University Of Sao Paulo

• SATO Go

  Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

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