Possible Physiological Roles of Proteolytic Products of Actin in Neutrophils of Patients with Behcet's Disease
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概要
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A truncated actin with an N-terminus of Met-44 is known to be selectively increased in neutrophils of patients with Behcet's disease and to be generated proteolytically by PMN-elastase(Yamashita S.et al., Biol.Pharm.Bull., 23, 519-522(2000) ; Biol.Pharm.Bull., 24, 119-122(2001)). In this study, the functions of the N-terminal peptide consisting of Asp-2 to Val-43 of β-actin(42-merP)and the truncated actin with an N-terminus of Met-44 were examined. We first confirmed that the 42-merP existed in the patient plasma. The motility of human peripheral blood neutrophils and neutrophilic granulocytes differentiated from HL-60 cells was suppressed by the 42-merP. Furthermore, when neutrophil-like cells from HL-60 cells were preincubated with 10nM 42-merP, migration of the cells induced by chemotactic factors such as fMLP and IL-8 was suppressed. The release of PMN-elastase, which is a neutrophil granular enzyme that is responsible for the prodution of the 42-merP and truncated actin, was suppressed by pretreating the neutrophils with 42-merP before fMLP-stimulation. The truncated actin was unable to polymerize in 0.1_M KC1, suggesting that the increase of truncated actin damages the reconstitution capacity of actin in neutrophils of the patients. These results suggest that the increase of 42-merP and truncated actin in patients with Behcet's disease changes functions of neutrophils
- 社団法人日本薬学会の論文
- 2001-07-01
著者
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Suzuki Akiko
Departments of Radiology, Yokohama City University, School of Medicine
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TOYOSHIMA Satoshi
Department of Pathology, Kitakyushu Municipal Medical Center
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Suzuki A
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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YAMASHITA Shozo
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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KAMADA Masafumi
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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YANAGITA Tamiko
Department of Internal Medicine, Teikyo University
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HIROHATA Shunsei
Department of Internal Medicine, Teikyo University
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Suzuki Akiko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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SUZUKI Akio
Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Toyoshima S
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Toyoshima S
Pharmaceuticals And Medical Devices Agency
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Toyoshima Satoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kamada Masafumi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Yanagita Tamiko
Department Of Internal Medicine Teikyo University
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Yamashita S
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Racing
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Hirohata Shunsei
Department Of Internal Medicine Teikyo University
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Sakane T
St. Marianna Univ. School Of Medicine Kanagawa Jpn
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Suzuki Akiko
Department Of Anesthesiology University Of Hirosaki School Of Medicine
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